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KMID : 0353320150390010055
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Oral Biology Research
2015 Volume.39 No. 1 p.55 ~ p.60
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Blocking β-adrenergic signaling mitigates reductions in bone marrow leptin expression seen with the high calorie diet
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Baek Kyung-Hwa
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Abstract
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Purpose: We previously demonstrated the following: 1) Magnitude of bone loss and marrow adiposity induced by low calorie diet are greater than those caused by high calorie diet and 2) b-adrenergic (b-AR) blockade mitigates bone loss induced by high calorie diet and marrow adiposity induced by high calorie and low calorie diets. In the present study, we evaluated the levels of leptin in serum and bone marrow to examine whether or not b-AR blockade-induced attenuation of bone loss is associated with leptin.
Materials and Methods: Male 6-week-old C57BL/6 mice were randomly assigned to one of three groups: ad-lib fed control diet (CON), high calorie diet (HIGH), and low calorie diet (LOW). In each diet group, 10 mice were treated with vehicle (VEH) while the other 10 mice were treated with propranolol, a b-AR antagonist (b-blocker; 0.5 g/L).
Results: Serum leptin level was higher in HIGHVEH mice and lower in LOWVEH mice than in CONVEH mice. b-AR blockade did not alter circulating serum leptin levels, but it increased leptin secretion per unit fat mass in high calorie diet-fed mice. Both high calorie and low calorie diets decreased bone marrow leptin expression. b-AR blockade mitigated reduction of bone marrow leptin expression levels seen in mice fed high calorie diet.
Conclusion: These data suggest that the b-AR signaling pathway plays a role in alteration of bone marrow adiposity in response to dietary calorie intake and that leptin is associated with b-AR-mediated regulation of bone and marrow fat.
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KEYWORD
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Beta-adrenergic receptor, Bone marrow, High calorie diet, Leptin, Propranolol
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